how to control stem cells ?

White Blood cells 

Scientists at the University of bathtub have known however a cistron in fish is concerned in dominant stem cells.

A new study from the cluster of academic Henry M. Robert Kelsh within the Department of Biology appearance at however a unique cluster of stem cells square measure controlled by mutations
in a gene called parade.

They identified a new set of stem cells in zebrafish, which eventually become skin pigment cells of different colours.

Populations of pigment stem cells are formed in the embryonic stages of development, but are then dormant and don't mature into a final cell type until adulthood. This development is controlled by a range of factors called the "stem cell niche—including surrounding cell types, blood supply and signals from nerves.

In parade mutants the zebrafish show large numbers of abnormally positioned pigment cells near the main blood vessels, lined up 'like soldiers on parade'.

The Bath team's work demonstrates that these pigment cells derive from this newly-discovered population of stem cells, thatwithin the parade mutants become activated long before traditional.

Their research also showed that the key problem in parade mutant lies in the blood vessels, indicating that the blood vessels form a crucial part of the niche controlling this group of stem cells.
Prof. Kelsh said: "This is that the 1st time that blood vessels are shown to assist management pigment stem cells, although they are a widespread feature of other stem cell niches.
We expect that a number of the factors dominant these pigment vegetative cells are going to be shared with different stem cell niches."

Karen Camargo-Sosa, the lead author whose Ph.D.
thesis work contributed to the present paper, added: "Our research has shown that the parade gene must regulate the signals controlling the division of adult pigment stem cells; this is
the first time the parade factor has been concerned in vegetative cell regulation."
The group is now poised to explore how these features of the pigment stem cell niche control their behaviour, identifying which chemical signals from the blood vessels hold the stem
cells in Associate in Nursing inactive state, and which drive them to metamorphose—what turns them off, and what turns them on.